ADAPT is a computational modeling platform developed for pharmacokinetic and pharmacodynamic applications. It is intended for basic and clinical research scientists and is designed to facilitate the discovery, exploration and application of the underlying pharmacokinetic and pharmacodynamic properties of drugs. ADAPT has been developed under the direction of David Z. D'Argenio in collaboration with Alan Schumitzky and Xiaoning Wang.
Since 1985, ADAPT has been developed and supported by the Biomedical Simulations Resource (BMSR) in the Department of Biomedical Engineering at the University of Southern California, under support from the National Institute for Biomedical Imaging and Bioengineering (P41-EB001978) and the National Center for Research Resources (P41-RR01861) of the National Institutes of Health. It is distributed by the BMSR at no charge to the user, under the terms of a Release Agreement. We ask that all users of ADAPT provide us with a completed Release Agreement so that we can maintain a database of ADAPT users.
Individual Analysis Capabilities
- Estimation module (ID) includes weighted least squares, maximum likelihood (ML), generalized least squares (GLS), maximum a posterior Bayesian estimation (MAP)
- Simulation module (SIM) includes capabilities for single and multisubject simulations
- Sample schedule design module (SAMPLE) provides the ability to calculate D- and C-optimal designs
- Parametric population PK/PD modeling using maximum likelihood estimation via the EM algorithm with sampling, as introduced by Schumitzky (1995) and by Walker (1996), with general user defined second stage covariate models and first stage error variance models.
- Iterated two-stage (ITS) analysis as proposed by Prevost (1977) and Steimer, Mallet and colleagues (1984), with general covariate and error variance models.
- Convenient standard two-stage
(STS) and naive pooled data (NPD) modeling, each with WLS, ML, and MAP
estimators.
System
Requirements
Operating
System
Windows 2000/XP/Server 2003/Vista
Intel Visual Fortran 9.1-11.1
or
Compaq 6.6
Additional Software Available
ADAPT II Release 4
S-ADAPT
S-ADAPT-TRAN
